The importance of kidney volume as a marker in the assessment of living-donor kidney transplantation in Japan.
Clin Exp Nephrol
; 25(5): 537-544, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33411116
ABSTRACT
BACKGROUND:
In living kidney transplantation, predicting the risk of end-stage kidney disease in the organ donors though crucial remains to be resolved. Thus, any useful biomarker to predict kidney outcome would be highly desirable to safeguard donors.METHODS:
This retrospective study was conducted at Nagoya Daini Red Cross Hospital to confirm whether an increase in preserved kidney volume (PKV) was a predict marker of proteinuria. A change of PKV before and 1 year after kidney donation was measured, and its association with proteinuria 3 years after the donation was analyzed.RESULTS:
A total of 119 kidney donors who met the Japanese donor guideline were enrolled. The mean age was 57.4 years, 46.2% were male. The mean values of the variables before kidney donation (baseline) were BMI levels 23.4 kg/m2, BSA-adjusted PKV 132.9 cm3/1.73 m2, and estimated glomerular filtration rate (eGFRave) 82.9 mL/min/1.73 m2. A positive correlation was noted between BSA-adjusted PKV and eGFRave (r = 0.61, p < 0.001). BSA-adjusted PKV increased by 19.5% 1 year after donation, and the median urine protein was 0.04 g/gCre. Linear regression analyses showed that change of PKV and BSA-adjusted PKV before the donation were significantly associated with proteinuria 3 years after donation.CONCLUSION:
Change of PKV and BSA-adjusted PKV before donation is important factors for proteinuria after donation under the Japanese donor guidelines. Further studies are needed to confirm whether these factors are associated with renal survival after donation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteinúria
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Transplante de Rim
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Doadores Vivos
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Rim
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Nefrectomia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article