Long-Time Phase Correlations Reveal Regulation of Beating Cardiomyocytes.
Phys Rev Lett
; 125(25): 258101, 2020 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-33416366
ABSTRACT
Spontaneous contractions of cardiomyocytes are driven by calcium oscillations due to the activity of ionic calcium channels and pumps. The beating phase is related to the time-dependent deviation of the oscillations from their average frequency, due to noise and the resulting cellular response. Here, we demonstrate experimentally that, in addition to the short-time (1-2 Hz), beat-to-beat variability, there are long-time correlations (tens of minutes) in the beating phase dynamics of isolated cardiomyocytes. Our theoretical model relates these long-time correlations to cellular regulation that restores the frequency to its average, homeostatic value in response to stochastic perturbations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Miócitos Cardíacos
/
Modelos Cardiovasculares
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article