LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on Î³-aminobutyric acid type A receptors.

Zhao, Yi; An, Long; Guo, Shupan; Huang, Xiaoxing; Tian, Huajie; Liu, Li; Chen, Tao; Sun, Xun; Mei, Qibing; Wang, Rutao

Zhao, Yi; An, Long; Guo, Shupan; Huang, Xiaoxing; Tian, Huajie; Liu, Li; Chen, Tao; Sun, Xun; Mei, Qibing; Wang, Rutao.

Afiliação

Zhao Y; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, China.
An L; Pharmacology Research Center, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Guo S; Department of New Drug Research, Xi'An Libang Pharmaceutical Co, Xi'An, Shaanxi, China.
Huang X; Department of New Drug Research, Xi'An Libang Pharmaceutical Co, Xi'An, Shaanxi, China.
Tian H; Department of New Drug Research, Xi'An Libang Pharmaceutical Co, Xi'An, Shaanxi, China.
Liu L; Pharmacology Research Center, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Chen T; Pharmacology Research Center, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Sun X; Pharmacology Research Center, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Mei Q; Department of New Drug Research, Xi'An Libang Pharmaceutical Co, Xi'An, Shaanxi, China.
Wang R; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, China.

Epilepsia ; 62(1): 238-249, 2021 01.

Article em En | MEDLINE | ID: mdl-33417274

Assuntos

Anticonvulsivantes/farmacologia; Propofol/farmacologia; Receptores de GABA-A/efeitos dos fármacos; Convulsões/tratamento farmacológico; Estado Epiléptico/tratamento farmacológico; Animais; Comportamento Animal/efeitos dos fármacos; Bicuculina/toxicidade; Eletroencefalografia; Antagonistas de Receptores de GABA-A/toxicidade; Hipnóticos e Sedativos/farmacologia; Camundongos; Agonistas Muscarínicos/toxicidade; Pentilenotetrazol/toxicidade; Fenóis/farmacologia; Pilocarpina/toxicidade; Propofol/análogos & derivados; Ratos; Receptores de GABA-A/metabolismo; Convulsões/induzido quimicamente; Estado Epiléptico/induzido quimicamente

Palavras-chave

EEG; GABA; LMR-101; bicuculline; epilepsy; generalized tonic-clonic seizure; kainic acid; pentylenetetrazol; pilocarpine; propofol; radioligand binding; status epilepticus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Estado Epiléptico / Propofol / Receptores de GABA-A / Anticonvulsivantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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