Experimental Model Systems for Understanding Human Axonal Injury Responses.
Int J Mol Sci
; 22(2)2021 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-33418850
ABSTRACT
Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon regeneration, various experimental models have been utilized in vivo and in vitro. Here, we collate the key experimental models that revealed the important mechanisms regulating axon regeneration and degeneration in different systems. We also discuss the advantages of experimenting with the rodent model, considering the application of these findings in understanding human diseases and for developing therapeutic methods.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Modelos Teóricos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article