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SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.
Hou, Guojun; Harley, Isaac T W; Lu, Xiaoming; Zhou, Tian; Xu, Ning; Yao, Chao; Qin, Yuting; Ouyang, Ye; Ma, Jianyang; Zhu, Xinyi; Yu, Xiang; Xu, Hong; Dai, Dai; Ding, Huihua; Yin, Zhihua; Ye, Zhizhong; Deng, Jun; Zhou, Mi; Tang, Yuanjia; Namjou, Bahram; Guo, Ya; Weirauch, Matthew T; Kottyan, Leah C; Harley, John B; Shen, Nan.
Afiliação
  • Hou G; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Harley ITW; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200032, China.
  • Lu X; Shanghai Institute of Rheumatology, China-Australia Centre for Personalized Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Zhou T; Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China.
  • Xu N; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.
  • Yao C; Division of Rheumatology, School of Medicine, University of Colorado, Aurora, Colorado, 80045, USA.
  • Qin Y; Department of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, Colorado, 80045, USA.
  • Ouyang Y; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.
  • Ma J; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Zhu X; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Yu X; Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences(SIBS), University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, 200031, China.
  • Xu H; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Dai D; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Ding H; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Yin Z; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Ye Z; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Deng J; Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China.
  • Zhou M; Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200127, China.
  • Tang Y; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Namjou B; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Guo Y; Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China.
  • Weirauch MT; Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, 518040, China.
  • Kottyan LC; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
  • Harley JB; Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (SJTU), Shanghai, 200240, China.
  • Shen N; Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200001, China.
Nat Commun ; 12(1): 135, 2021 01 08.
Article em En | MEDLINE | ID: mdl-33420081
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sequências Reguladoras de Ácido Nucleico / MicroRNAs / Epigênese Genética / Lúpus Eritematoso Sistêmico Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sequências Reguladoras de Ácido Nucleico / MicroRNAs / Epigênese Genética / Lúpus Eritematoso Sistêmico Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article