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Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists.
Ruan, Zheming; Park, Peter K; Wei, Donna; Purandare, Ashok; Wan, Honghe; O'Malley, Daniel; Stachura, Sylwia; Perez, Heidi; Cavallaro, Cullen L; Weigelt, Carolyn A; Sack, John S; Ruzanov, Max; Khan, Javed; Gururajan, Murali; Wong, Jessica J; Huang, Yanling; Yarde, Melissa; Li, Zhuyin; Chen, Cliff; Sun, Huadong; Borowski, Virna; Xie, Jenny H; Anthony, Monique; Agler, Michele; Fink, Brian E; Harikrishnan, Lalgudi S.
Afiliação
  • Ruan Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA. Electronic address: zheming.ruan@bms.com.
  • Park PK; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Wei D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Purandare A; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Wan H; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • O'Malley D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Stachura S; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Perez H; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Cavallaro CL; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Weigelt CA; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Sack JS; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Ruzanov M; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Khan J; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Gururajan M; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Wong JJ; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Huang Y; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Yarde M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Li Z; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Chen C; Preclinical Candidate Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Sun H; Preclinical Candidate Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Borowski V; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Xie JH; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Anthony M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Agler M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Fink BE; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
  • Harikrishnan LS; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
Bioorg Med Chem Lett ; 35: 127778, 2021 03 01.
Article em En | MEDLINE | ID: mdl-33422603
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Éteres / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Éteres / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article