Insight into the formation of N-nitrosodimethylamine in metformin products.

Jires, Jakub; Kalásek, Stanislav; Gibala, Petr; Rudovský, Jakub; Dousa, Michal; Kubelka, Tomás; Hrubý, Jan; Rezanka, Pavel

Jires, Jakub; Kalásek, Stanislav; Gibala, Petr; Rudovský, Jakub; Dousa, Michal; Kubelka, Tomás; Hrubý, Jan; Rezanka, Pavel.

Afiliação

Jires J; Department of Analytical Chemistry, Faculty of Chemical Engineering, UCT Prague, Technická 5, 166 28, Prague 6, Czech Republic.
Kalásek S; Zentiva, k.s. Praha, U Kabelovny 130, 102 37, Prague 10, Czech Republic.
Gibala P; Zentiva, k.s. Praha, U Kabelovny 130, 102 37, Prague 10, Czech Republic.
Rudovský J; Quinta Analytica, s.r.o. Prazská 1486/18c, 102 00, Prague 10, Czech Republic.
Dousa M; Zentiva, k.s. Praha, U Kabelovny 130, 102 37, Prague 10, Czech Republic. Electronic address: michal.dousa@seznam.cz.
Kubelka T; Zentiva, k.s. Praha, U Kabelovny 130, 102 37, Prague 10, Czech Republic.
Hrubý J; Zentiva, k.s. Praha, U Kabelovny 130, 102 37, Prague 10, Czech Republic.
Rezanka P; Department of Analytical Chemistry, Faculty of Chemical Engineering, UCT Prague, Technická 5, 166 28, Prague 6, Czech Republic.

J Pharm Biomed Anal ; 195: 113877, 2021 Feb 20.

Article em En | MEDLINE | ID: mdl-33422831

Assuntos

Dimetilnitrosamina; Metformina; Cromatografia Líquida de Alta Pressão; Cromatografia Líquida; Contaminação de Medicamentos; Reprodutibilidade dos Testes; Espectrometria de Massas em Tandem

Palavras-chave

Metformin; N-nitrosamines; N-nitrosodimethylamine; Pharmaceutical analysis; Tandem mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dimetilnitrosamina / Metformina Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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