Whey proteins inhibit food intake and tend to improve oxidative balance in obese zucker rats.
Eat Weight Disord
; 26(8): 2453-2461, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-33426629
ABSTRACT
BACKGROUND/AIMS:
Whey proteins (WP), obtained from milk after casein precipitation, represent a heterogeneous group of proteins. WP are reported to inhibit food intake in diet-induced experimental obesity; WP have been proposed as adjuvant therapy in oxidative stress-correlated pathologies. This work evaluates the effects of WP in comparison with casein, as a source of alimentary proteins, on food intake, weight growth and some indexes of oxidative equilibrium in Zucker Rats, genetically prone to obesity.METHODS:
We monitored food intake and weight of Zucker Rats during the experiment, and some markers of oxidative equilibrium.RESULTS:
WP induced significant decrease of food intake in comparison to casein (WP 80.41 ± 1.069 ml/day; CAS 88.95 ± 1.084 ml/day; p < 0.0005). Body weight growth was slightly reduced, and the difference was just significant (WP 128.2 ± 6.56 g/day; CAS 145.2 ± 3.29 g/day; p = 0.049), while plasma HNE level was significantly lower in WP than in CAS (WP 41.2 ± 6.3 vs CAS 69.61 ± 4.69 pmol/ml, p = 0.007). Mild amelioration of oxidative equilibrium was indicated by a slight increase of total glutathione both in the liver and in the blood and a significant decrease of plasma 4-hydroxynonenal in the group receiving WP.CONCLUSIONS:
The effect of WP on food intake and weight growth in Zucker Rats is particularly noteworthy since the nature of their predisposition to obesity is genetic; the possible parallel amelioration of the oxidative balance may constitute a further advantage of WP since oxidative stress is believed to be interwoven to obesity, metabolic syndrome and their complications.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Obesidade
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article