miRNA landscape in primary tumors and matched metastases in gastrointestinal stromal tumors.
Epigenomics
; 13(5): 369-377, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33432846
ABSTRACT
Aim:
Gastrointestinal stromal tumor management is extremely challenging, particularly the metastatic disease. The underlying mechanism in metastasis spread remains largely unknown. We aimed to characterize miRNAs involved in the metastatic process in gastrointestinal stromal tumor. Material &methods:
Eight primary tumors and 18 synchronous metastases were analyzed through miRNA Taqman arrays or assays.Results:
miRNAs profiles revealed similar expression in primary site and metastases. Pair-wise correlation coefficient between primary tumor and metastases was significant for each patient (p < 0.0001 for all profiled patients).Conclusion:
Our study, the largest including primary tumors and metastases so far performed, highlighted perpetuation of miRNAs features in metastatic lesions and that the primary origin appears to be the main determinant of the metastases miRNA profile.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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MicroRNAs
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Tumores do Estroma Gastrointestinal
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Neoplasias Gastrointestinais
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article