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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.
Qing, Ying; Dong, Lei; Gao, Lei; Li, Chenying; Li, Yangchan; Han, Li; Prince, Emily; Tan, Brandon; Deng, Xiaolan; Wetzel, Collin; Shen, Chao; Gao, Min; Chen, Zhenhua; Li, Wei; Zhang, Bin; Braas, Daniel; Ten Hoeve, Johanna; Sanchez, Gerardo Javier; Chen, Huiying; Chan, Lai N; Chen, Chun-Wei; Ann, David; Jiang, Lei; Müschen, Markus; Marcucci, Guido; Plas, David R; Li, Zejuan; Su, Rui; Chen, Jianjun.
Afiliação
  • Qing Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
  • Dong L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Gao L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Pathology and Genomic Medicine, Houston Methodist, Houston, TX 77030, USA.
  • Li C; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Key Laboratory of Hematopoietic Malignancies, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 31003, China.
  • Li Y; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
  • Han L; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, China.
  • Prince E; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Tan B; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Deng X; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Wetzel C; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
  • Shen C; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Gao M; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineer (Tianjin), Ti
  • Chen Z; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Li W; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Zhang B; Department of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA; Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA.
  • Braas D; UCLA Metabolomics Center, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ten Hoeve J; UCLA Metabolomics Center, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Sanchez GJ; UCLA Metabolomics Center, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Chen H; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
  • Chan LN; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Internal Medicine (Hematology) and Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06511, USA.
  • Chen CW; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA.
  • Ann D; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; City of Hope Comprehensive Cancer Center, City of Hope,
  • Jiang L; Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA.
  • Müschen M; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA; Department of Internal Medicine (Hematology) and Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale Scho
  • Marcucci G; Department of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA; Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA.
  • Plas DR; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
  • Li Z; Department of Pathology and Genomic Medicine, Houston Methodist, Houston, TX 77030, USA.
  • Su R; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: rsu@coh.org.
  • Chen J; Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA; Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA. Electronic address: jianchen@coh.org.
Mol Cell ; 81(5): 922-939.e9, 2021 03 04.
Article em En | MEDLINE | ID: mdl-33434505
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Fosfofrutoquinase-1 Tipo C / Lactato Desidrogenases / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Glutaratos / Glicólise / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Fosfofrutoquinase-1 Tipo C / Lactato Desidrogenases / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Glutaratos / Glicólise / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article