Fostamatinib is an effective second-line therapy in patients with immune thrombocytopenia.
Br J Haematol
; 190(6): 933-938, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-33439486
ABSTRACT
Fostamatinib demonstrated efficacy in phase 3 trials of adults with immune thrombocytopenia (ITP). Post hoc analysis compared patients who received fostamatinib as second-line therapy (after steroids ± immunoglobulins) versus third-or-later-line therapy (after ≥2 prior lines of therapy including a second-line agent). Platelet responses ≥50 000/µl were observed in 25/32 (78%) second-line and 54/113 (48%) third-or-later-line patients. Bleeding events were less frequent in second-line (28%) versus third-or-later-line (45%) patients. Responses once achieved tended to be durable in both groups. The safety profile was similar in both groups. In this post hoc analysis, fostamatinib was more effective as second-line than third-or-later-line therapy for ITP.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Piridinas
/
Púrpura Trombocitopênica Idiopática
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article