GATA6 is a regulator of sinus node development and heart rhythm.

Gharibeh, Lara; Yamak, Abir; Whitcomb, Jamieson; Lu, Aizhu; Joyal, Mathieu; Komati, Hiba; Liang, Wenbin; Fiset, Céline; Nemer, Mona

Gharibeh, Lara; Yamak, Abir; Whitcomb, Jamieson; Lu, Aizhu; Joyal, Mathieu; Komati, Hiba; Liang, Wenbin; Fiset, Céline; Nemer, Mona.

Afiliação

Gharibeh L; Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
Yamak A; Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
Whitcomb J; Cardiovascular Research Center, Harvard Medical School, Boston, MA 02115.
Lu A; Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
Joyal M; Cardiovascular Electrophysiology Laboratory, University of Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada K1Y 4W7.
Komati H; Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
Liang W; Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5.
Fiset C; Cardiovascular Electrophysiology Laboratory, University of Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada K1Y 4W7.
Nemer M; Research Center, Montreal Heart Institute, Montreal, QC, Canada H1T 1C8.

Proc Natl Acad Sci U S A ; 118(1)2021 01 05.

Article em En | MEDLINE | ID: mdl-33443158

Assuntos

Fator de Transcrição GATA6/metabolismo; Frequência Cardíaca/fisiologia; Nó Sinoatrial/embriologia; Animais; Arritmias Cardíacas/fisiopatologia; Diferenciação Celular/genética; Fator de Transcrição GATA6/genética; Regulação da Expressão Gênica no Desenvolvimento/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Organogênese; Nó Sinoatrial/fisiologia; Proteínas com Domínio T/genética

Palavras-chave

GATA proteins; TBX3; cardiac conduction system; heart development; sinus node

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nó Sinoatrial / Fator de Transcrição GATA6 / Frequência Cardíaca Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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