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From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health.
Mews, Philipp; Calipari, Erin S; Day, Jeremy; Lobo, Mary Kay; Bredy, Timothy; Abel, Ted.
Afiliação
  • Mews P; Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10129 philipp.mews@mssm.edu.
  • Calipari ES; Departments of Pharmacology, Molecular Physiology and Biophysics, Psychiatry and Behavioral Sciences; Vanderbilt Center for Addiction Research; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37323.
  • Day J; Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294.
  • Lobo MK; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
  • Bredy T; Queensland Brain Institute, University of Queensland, Brisbane, 4072, Australia.
  • Abel T; Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242.
J Neurosci ; 41(5): 873-882, 2021 02 03.
Article em En | MEDLINE | ID: mdl-33446519
A central goal of neuroscience research is to understand how experiences modify brain circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit activity engages gene regulatory mechanisms within each cell. This activity-dependent gene expression is governed, in part, by epigenetic processes that can produce persistent changes in both neural circuits and the epigenome itself. The complex interplay between circuit activity and neuronal gene regulation is vital to learning and memory, and, when disrupted, is linked to debilitating psychiatric conditions, such as substance use disorder. To develop clinical treatments, it is paramount to advance our understanding of how neural circuits and the epigenome cooperate to produce behavioral adaptation. Here, we discuss how new genetic tools, used to manipulate neural circuits and chromatin, have enabled the discovery of epigenetic processes that bring about long-lasting changes in behavior relevant to mental health and disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Cromatina / Saúde Mental / Transtornos Relacionados ao Uso de Substâncias / Epigênese Genética / Rede Nervosa Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Cromatina / Saúde Mental / Transtornos Relacionados ao Uso de Substâncias / Epigênese Genética / Rede Nervosa Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article