Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila.
Exp Cell Res
; 399(2): 112486, 2021 02 15.
Article
em En
| MEDLINE
| ID: mdl-33450208
ABSTRACT
Dynamic changes in mitochondrial shape and size are vital for mitochondrial health and for tissue development and function. Adult Drosophila indirect flight muscles contain densely packed mitochondria. We show here that mitochondrial fusion is critical during early muscle development (in pupa) and that silencing of the outer mitochondrial membrane fusion gene, Marf, in muscles results in smaller mitochondria that are functionally defective. This leads to abnormal muscle development resulting in muscle dysfunction in adult flies. However, post-developmental silencing of Marf has no obvious effects on mitochondrial and muscle phenotype in adult flies, indicating the importance of mitochondrial fusion during early muscle development.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Drosophila
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Desenvolvimento Muscular
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Drosophila melanogaster
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Dinâmica Mitocondrial
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Voo Animal
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article