Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.
Clin Neurophysiol
; 132(2): 568-580, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33450578
ABSTRACT
OBJECTIVE:
Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source imaging of FO using 256-channel high-density EEG (HD-EEG) is useful for EZ identification.METHODS:
We analyzed HD-EEG recordings of 10 focal drug-resistant epilepsy patients with seizure-free postsurgical outcome. We marked FO candidate events at the time of epileptic spikes and verified them by screening for an isolated peak in the time-frequency plot. We performed electrical source imaging of spikes and FO within the Maximum Entropy of the Mean framework. Source localization maps were validated against the surgical cavity.RESULTS:
We identified FO in five out of 10 patients who had a superficial or intermediate deep generator. The maximum of the FO maps was localized inside the cavity in all patients (100%). Analysis with a reduced electrode coverage using the 10-10 and 10-20 system showed a decreased localization accuracy of 60% and 40% respectively.CONCLUSIONS:
FO recorded with HD-EEG localize the EZ. HD-EEG is better suited to detect and localize FO than conventional EEG approaches.SIGNIFICANCE:
This study acts as proof-of-concept that FO localization using 256-channel HD-EEG is a viable marker of the EZ.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mapeamento Encefálico
/
Eletroencefalografia
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Epilepsia Resistente a Medicamentos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article