Ionising radiation causes vision impairment in neonatal B6C3F1 mice.
Exp Eye Res
; 204: 108432, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33454312
ABSTRACT
Ionising radiation interacts with lenses and retinae differently. In human lenses, posterior subcapsular cataracts are the predominant observation, whereas retinae of adults are comparably resistant to even relatively high doses. In this study, we demonstrate the effects of 2 Gy of low linear energy transfer ionising radiation on eyes of B6C3F1 mice aged postnatal day 2. Optical coherence tomography and Scheimpflug imaging were utilised for the first time to monitor murine lenses and retinae in vivo. The visual acuity of the mice was determined and histological analysis was conducted. Our results demonstrated that visual acuity was reduced by as much as 50 % approximately 9 months after irradiation in irradiated mice. Vision impairment was caused by retinal atrophy and inner cortical cataracts. These results help to further our understanding of the risk of ionising radiation for human foeti (â¼ 8 mo), which follow the same eye development stages as neonatal mice.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
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Radiação Ionizante
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Retina
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Doenças Retinianas
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Transtornos da Visão
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Catarata
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Cristalino
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article