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A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy.
Wang, Jian-Tao; Yu, Zhong-Yu; Tao, Ying-Hong; Liu, Ying-Chao; Wang, Yan-Mei; Guo, Qi-Lin; Xue, Jian-Zhong; Wen, Xiao-Hong; Zhang, Qian; Xu, Xiao-Die; He, Cheng-Feng; Xue, Wen-Jiao; Guo, Jing-Chun; Zhou, Hou-Guang.
Afiliação
  • Wang JT; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
  • Yu ZY; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
  • Tao YH; Department of Medical Examination Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Liu YC; Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
  • Wang YM; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
  • Guo QL; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Xue JZ; Department of Neurology, Fifth Clinical Medical College of Yangzhou University, Changshu Second People's Hospital of Jiangsu Province, Changshu, China.
  • Wen XH; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Zhang Q; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Xu XD; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • He CF; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Xue WJ; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Guo JC; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.
  • Zhou HG; Department of Geriatric Neurology of Huashan Hospital, National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China.
CNS Neurosci Ther ; 27(4): 484-496, 2021 04.
Article em En | MEDLINE | ID: mdl-33459523
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Ácidos Esteáricos / Fármacos Neuroprotetores / Ácido Palmítico / Serina-Treonina Quinases TOR / Proteína Homóloga à Proteína-1 Relacionada à Autofagia Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Ácidos Esteáricos / Fármacos Neuroprotetores / Ácido Palmítico / Serina-Treonina Quinases TOR / Proteína Homóloga à Proteína-1 Relacionada à Autofagia Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article