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Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.
Schmitt, Kimberly; Curlin, James; Remling-Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh.
Afiliação
  • Schmitt K; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Curlin J; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Moriarty R; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Goff K; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • O'Connor S; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Stenglein M; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Marx P; Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Akkina R; Tulane National Primate Research Center, Covington, LA, USA.
J Med Primatol ; 49(5): 284-287, 2020 10.
Article em En | MEDLINE | ID: mdl-33460210
ABSTRACT
HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4+ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pan troglodytes / HIV-1 / Vírus da Imunodeficiência Símia / Doenças dos Símios Antropoides / Mutação Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pan troglodytes / HIV-1 / Vírus da Imunodeficiência Símia / Doenças dos Símios Antropoides / Mutação Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article