Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease.

Estevez-Fraga, Carlos; Scahill, Rachael I; Durr, Alexandra; Leavitt, Blair R; Roos, Raymund A C; Langbehn, Douglas R; Rees, Geraint; Gregory, Sarah; Tabrizi, Sarah J

Estevez-Fraga, Carlos; Scahill, Rachael I; Durr, Alexandra; Leavitt, Blair R; Roos, Raymund A C; Langbehn, Douglas R; Rees, Geraint; Gregory, Sarah; Tabrizi, Sarah J.

Afiliação

Estevez-Fraga C; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Scahill RI; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Durr A; Sorbonne Université, Paris Brain Institute (ICM), AP-HP, Inserm, CNRS, Pitié-Salpêtrière University Hospital, Paris, France.
Leavitt BR; Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Roos RAC; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Langbehn DR; Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA.
Rees G; Wellcome Centre for Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Gregory S; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Tabrizi SJ; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.

Mov Disord ; 36(5): 1259-1264, 2021 05.

Article em En | MEDLINE | ID: mdl-33471951

Assuntos

Doença de Huntington; Substância Branca; Anisotropia; Atrofia/patologia; Biomarcadores; Progressão da Doença; Humanos; Doença de Huntington/diagnóstico por imagem; Doença de Huntington/patologia; Imageamento por Ressonância Magnética; Substância Branca/diagnóstico por imagem; Substância Branca/patologia

Palavras-chave

Huntington's disease; composite Unified Huntington's Disease Rating Scale; diffusion tensor imaging; voxel-based morphometry; clinical trials; longitudinal

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Huntington / Substância Branca Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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