Dispensability of Tubulin Acetylation for 15-protofilament Microtubule Formation in the Mammalian Cochlea.
Cell Struct Funct
; 46(1): 11-20, 2021 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-33473065
ABSTRACT
The development of hearing in mammals requires the formation and maturation of a highly organized and specialized epithelium known as the organ of Corti. This epithelium contains two types of cells, the sensory cells, which are the true receptors of auditory information, and the surrounding supporting cells, which are composed of a highly developed cytoskeleton essential to the architecture of the mature organ of Corti. The supporting cells are the only mammalian cells reported to contain the unusual 15-protofilament microtubules. In this paper, we show that 15-protofilament microtubules appear between the second and fourth day after birth in the pillar cells of the organ of Corti in mice. We also show that contrary to what has been described in the nematode worm Caenorhabiditis. elegans, microtubule acetylation is not essential for the formation of 15-protofilament microtubules in mice but is required for fine-tuning of their diameter.Key words Acetylation, cytoskeleton, microtubule, inner ear, supporting cells.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article