Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.

Abolhasani, Hoda; Zarghi, Afshin; Komeili Movahhed, Tahereh; Abolhasani, Ahmad; Daraei, Bahram; Dastmalchi, Siavoush

Abolhasani, Hoda; Zarghi, Afshin; Komeili Movahhed, Tahereh; Abolhasani, Ahmad; Daraei, Bahram; Dastmalchi, Siavoush.

Afiliação

Abolhasani H; Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran; Health Spirituality Research Center, Qom University of Medical Sciences, Qom, Iran; Department of Pharmacology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Zarghi A; Department of Medicinal and Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Komeili Movahhed T; Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Abolhasani A; Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Daraei B; Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dastmalchi S; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Near East University, POBOX:99138, Nicosia, North Cyprus, Mersin 10, Turkey. Electronic

Bioorg Med Chem ; 32: 115960, 2021 02 15.

Article em En | MEDLINE | ID: mdl-33477020

Assuntos

Antineoplásicos/farmacologia; Inibidores de Ciclo-Oxigenase 2/farmacologia; Ciclo-Oxigenase 2/metabolismo; Desenho de Fármacos; Indanos/farmacologia; Isoxazóis/farmacologia; Compostos de Espiro/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Inibidores de Ciclo-Oxigenase 2/síntese química; Inibidores de Ciclo-Oxigenase 2/química; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Indanos/síntese química; Indanos/química; Isoxazóis/química; Estrutura Molecular; Compostos de Espiro/química; Relação Estrutura-Atividade

Palavras-chave

Apoptosis; Cytotoxicity; Docking; Indanone; MTT assay; Molecular dynamics simulation; Selective COX-2 inhibitors; Spiroisoxazoline; Synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Desenho de Fármacos / Ciclo-Oxigenase 2 / Inibidores de Ciclo-Oxigenase 2 / Indanos / Isoxazóis / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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