Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69-V70, France, August to December 2020.
Euro Surveill
; 26(3)2021 01.
Article
em En
| MEDLINE
| ID: mdl-33478625
ABSTRACT
We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69-V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including SN501Y in the VOC.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sequência de Bases
/
Genoma Viral
/
Deleção de Sequência
/
Glicoproteína da Espícula de Coronavírus
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SARS-CoV-2
/
COVID-19
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article