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Polypseudorotaxane-based supramolecular hydrogels consisting of cyclodextrins and Pluronics as stabilizing agents for antibody drugs.
Ohshita, Naoko; Motoyama, Keiichi; Iohara, Daisuke; Hirayama, Fumitoshi; Taharabaru, Toru; Watabe, Naoki; Kawabata, Youhei; Onodera, Risako; Higashi, Taishi.
Afiliação
  • Ohshita N; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Motoyama K; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Iohara D; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
  • Hirayama F; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
  • Taharabaru T; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Watabe N; Renishaw plc. 4-29-8 Yotsuya, Shinjuku-ku, Tokyo 160-0004, Japan.
  • Kawabata Y; Renishaw plc. 4-29-8 Yotsuya, Shinjuku-ku, Tokyo 160-0004, Japan; Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan.
  • Onodera R; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Higashi T; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: higashit@kumamoto-u.ac.jp.
Carbohydr Polym ; 256: 117419, 2021 Mar 15.
Article em En | MEDLINE | ID: mdl-33483011
ABSTRACT
Recently, antibody drugs have been used worldwide, and based on worldwide sales, 7 of the top 10 pharmaceutical products in 2019 were antibody-based drugs. However, antibody drugs often form aggregates upon thermal and shaking stresses with few efficient stabilizing agents against both stresses. Herein, we developed polypseudorotaxane (PpRX) hydrogels consisting of cyclodextrins (CyDs) and polyethylene glycol (PEG)-polypropylene glycol (PPG)-PEG block copolymers (Pluronics F108, F87, F68, and L44), and evaluated their utility as antibody stabilizing agents. α- and γ-CyDs formed PpRX hydrogels with Pluronics, where CyD/F108 gels showed remarkable stabilizing effects for human immunoglobulin G (IgG) against both thermal and shaking stresses beyond CyD/PEG gels or generic gels. The effects were probably due to the interaction between IgG and the free PPG block of Pluronic F108, resulting in the strong IgG retention in the gels. These findings suggest the great potential of CyD/Pluronic gels as pharmaceutical materials for antibody formulations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Poloxâmero / Hidrogéis / Ciclodextrinas / Composição de Medicamentos / Excipientes / Anticorpos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Poloxâmero / Hidrogéis / Ciclodextrinas / Composição de Medicamentos / Excipientes / Anticorpos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article