ß­Lapachone ameliorates L­DOPA­induced dyskinesia in a 6­OHDA­induced mouse model of Parkinson's disease.

Ryu, Young-Kyoung; Park, Hye-Yeon; Go, Jun; Lee, In-Bok; Choi, Young-Keun; Lee, Chul-Ho; Kim, Kyoung-Shim

ßLapachone ameliorates LDOPAinduced dyskinesia in a 6OHDAinduced mouse model of Parkinson's disease.

Ryu, Young-Kyoung; Park, Hye-Yeon; Go, Jun; Lee, In-Bok; Choi, Young-Keun; Lee, Chul-Ho; Kim, Kyoung-Shim.

Afiliação

Ryu YK; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Park HY; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Go J; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Lee IB; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Choi YK; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Lee CH; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Kim KS; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

Mol Med Rep ; 23(3)2021 03.

Article em En | MEDLINE | ID: mdl-33495840

Assuntos

Discinesias; Levodopa/efeitos adversos; Naftoquinonas/farmacologia; Oxidopamina/efeitos adversos; Doença de Parkinson Secundária; Animais; Discinesias/tratamento farmacológico; Discinesias/metabolismo; Discinesias/patologia; Levodopa/farmacologia; Masculino; Camundongos; Oxidopamina/farmacologia; Doença de Parkinson Secundária/induzido quimicamente; Doença de Parkinson Secundária/tratamento farmacológico; Doença de Parkinson Secundária/metabolismo; Doença de Parkinson Secundária/patologia

Palavras-chave

ßLapachone; Parkinson's disease; 3,4dihydroxyphenyllalanineinduced dyskinesia; glycogen synthase kinase 3ß; astrocyte activation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Secundária / Levodopa / Naftoquinonas / Oxidopamina / Discinesias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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