[Correlation between gut microbiota and liver biochemical indicators in patients with chronic hepatitis B].
Sheng Wu Gong Cheng Xue Bao
; 37(1): 301-311, 2021 Jan 25.
Article
em Zh
| MEDLINE
| ID: mdl-33501810
ABSTRACT
Chronic hepatitis B (CHB) is a global epidemic disease caused by hepatitis B virus that can lead to hepatic failure, even liver cirrhosis and hepatocellular carcinoma. The occurrence and development of CHB are closely related to the changes in the gut microbiota communities. To explore the relationship between the structure of gut microbiota and liver biochemical indicators, 14 CHB patients (the CHB group) and 11 healthy people (the CN group) were randomly enrolled in this study. Our results demonstrate that CHB caused changes in the gut microbiota communities and biochemical indicators, such as alanine transaminase, total bilirubin and gamma glutamyl transferase. Furthermore, CHB induced imbalance of the gut microbiota. Prevotella, Blautia, Ruminococcus, Eubacterium eligens group, Bacteroides uniformis and Ruminococcus sp. 5_1_39BFAA were associated with the critical biochemical indicators and liver injury, suggesting a new approach to CHB treatment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hepatite B Crônica
/
Microbioma Gastrointestinal
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2021
Tipo de documento:
Article