New HIV infections from blood transfusions averted in 28 countries supported by PEPFAR blood safety programs, 2004-2015.
Transfusion
; 61(3): 851-861, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33506960
ABSTRACT
BACKGROUND:
To quantify the impact of the US President's Emergency Plan for AIDS Relief (PEPFAR) on the risk of HIV transmission through infected blood donations in countries supported by PEPFAR blood safety programs.METHODS:
Data reported to the World Health Organization Global Database on Blood Safety were analyzed from 28 countries in sub-Saharan Africa (SSA), Asia, and the Caribbean during 2004-2015. We used the Goals model of Spectrum Spectrum System Software, version 5.53, to perform the modeling, assuming laboratory quality for HIV testing had 91.9% sensitivity and 97.7% specificity irrespective of testing method based on results of two external quality assurance and proficiency testing studies of transfusion screening for HIV in SSA blood centers. We calculated the number of new HIV infections from the number of transfusions and the prevalence of HIV infection acquired from blood transfusions with infected blood donations. We determined the impact of laboratory testing programs by estimating the number of new HIV infections averted since PEPFAR implementation.RESULTS:
Assuming that HIV testing would not be performed in any of these countries without PEPFAR funding, the number of new HIV infections acquired from blood transfusions averted by laboratory testing increased over time in all 28 countries. The total number of HIV infections averted was estimated at 229 278 out of 20 428 373 blood transfusions during 2004-2015.CONCLUSION:
Our mathematical modeling suggests a positive impact achieved over 12 years of PEPFAR support for blood safety. Standardized HIV testing of donated blood has reduced the risk of HIV transmission through blood transfusions in SSA, Asia, and the Caribbean.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
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Infecções por HIV
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Reação Transfusional
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Programas Nacionais de Saúde
Tipo de estudo:
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Humans
País como assunto:
Africa
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Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article