Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding.

Yu, Jie; Dai, Yue; Fu, Yuxuan; Wang, Kezhen; Yang, Yang; Li, Min; Xu, Wei; Wei, Lin

Yu, Jie; Dai, Yue; Fu, Yuxuan; Wang, Kezhen; Yang, Yang; Li, Min; Xu, Wei; Wei, Lin.

Afiliação

Yu J; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Dai Y; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Fu Y; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Wang K; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Yang Y; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Li M; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
Xu W; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China. Electronic address: xuweifd828@126.com.
Wei L; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China. Electronic address: weilin1005@126.com.

Antiviral Res ; 187: 105021, 2021 03.

Article em En | MEDLINE | ID: mdl-33508330

Assuntos

Peptídeos Catiônicos Antimicrobianos/genética; Peptídeos Catiônicos Antimicrobianos/farmacologia; Enterovirus Humano A/efeitos dos fármacos; Imunidade; Ligação Viral/efeitos dos fármacos; Animais; Antivirais/farmacologia; Linhagem Celular; Chlorocebus aethiops; Enterovirus Humano A/genética; Infecções por Enterovirus/tratamento farmacológico; Infecções por Enterovirus/virologia; Interações entre Hospedeiro e Microrganismos; Humanos; Fator Regulador 3 de Interferon/metabolismo; Interferon beta/metabolismo; Interleucina-6/metabolismo; Camundongos; Camundongos Endogâmicos ICR; Fosforilação; RNA Viral; Regulação para Cima; Células Vero; Replicação Viral/efeitos dos fármacos; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Catelicidinas

Palavras-chave

Antimicrobial peptide; Cathelicidin; Enterovirus 71; Interferon-ß; Interlukin-6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Catiônicos Antimicrobianos / Enterovirus Humano A / Ligação Viral / Imunidade Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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