3-Phenoxypyridine 1-oxides as anticonvulsant agents.
J Med Chem
; 31(4): 841-7, 1988 Apr.
Article
em En
| MEDLINE
| ID: mdl-3351862
ABSTRACT
The anticonvulsant activity of a series of 3-phenoxypyridine 1-oxides is described. An investigation carried out to optimize the activity/side effect ratio provided 4-methyl-3-phenoxypyridine 1-oxide, 3, as the derivative of choice. Overall, 3 has a pharmacological profile that is very similar to phenytoin. It exhibited significant anticonvulsant activity at doses that did not produce ataxia or sedation but caused increased spontaneous behavioral activity not seen with most anticonvulsants. The short duration of pharmacological effect of 3 was attributed to metabolic hydroxylation at the C-4 pyridine methyl group; however, structural modifications designed to inhibit this metabolic pathway were unsuccessful.
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Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Óxidos N-Cíclicos
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article