Atropine-induced toxicity after off-label sublingual administration of eyedrop for sialorrhoea treatment in neurological disabled patients.
Br J Clin Pharmacol
; 87(8): 3364-3369, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33521988
ABSTRACT
Sialorrhea is a troublesome and disabling symptom defined by the unintentional loss of saliva from the mouth, usually associated with swallowing disorders. Today there is no consensus about the management of sialorrhoea, but off-label use of ophthalmic atropine eyedrop administered sublingually may offer benefits, despite limited safety data. We report 2 cases of atropine overdose after sublingual administration illustrating that atropine can expose to severe adverse effects when administered sublingually. The noncompartmental pharmacokinetic study of atropine performed in 1 patient highlighted that systemic absorption of sublingual atropine was effective (Cmax [1 h] = 2.2 ng mL-1 ; approximately) after a single dose of 1 mg.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sialorreia
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article