Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study.
Int J Cardiol
; 331: 333-339, 2021 05 15.
Article
em En
| MEDLINE
| ID: mdl-33524462
ABSTRACT
BACKGROUND:
QTc interval monitoring, for the prevention of drug-induced arrhythmias is necessary, especially in the context of coronavirus disease 2019 (COVID-19). For the provision of widespread use, surrogates for 12lead ECG QTc assessment may be useful. This prospective observational study compared QTc duration assessed by artificial intelligence (AI-QTc) (Cardiologs®, Paris, France) on smartwatch singlelead electrocardiograms (SW-ECGs) with those measured on 12lead ECGs, in patients with early stage COVID-19 treated with a hydroxychloroquine-azithromycin regimen.METHODS:
Consecutive patients with COVID-19 who needed hydroxychloroquine-azithromycin therapy, received a smartwatch (Withings Move ECG®, Withings, France). At baseline, day-6 and day-10, a 12lead ECG was recorded, and a SW-ECG was transmitted thereafter. Throughout the drug regimen, a SW-ECG was transmitted every morning at rest. Agreement between manual QTc measurement on a 12lead ECG and AI-QTc on the corresponding SW-ECG was assessed by the Bland-Altman method.RESULTS:
85 patients (30 men, mean age 38.3 ± 12.2 years) were included in the study. Fair agreement between manual and AI-QTc values was observed, particularly at day-10, where the delay between the 12lead ECG and the SW-ECG was the shortest (-2.6 ± 64.7 min) 407 ± 26 ms on the 12lead ECG vs 407 ± 22 ms on SW-ECG, bias -1 ms, limits of agreement -46 ms to +45 ms; the difference between the two measures was <50 ms in 98.2% of patients.CONCLUSION:
In real-world epidemic conditions, AI-QTc duration measured by SW-ECG is in fair agreement with manual measurements on 12lead ECGs. Following further validation, AI-assisted SW-ECGs may be suitable for QTc interval monitoring. REGISTRATION ClinicalTrial.govNCT04371744.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Síndrome do QT Longo
/
Inteligência Artificial
/
Eletrocardiografia
/
Tratamento Farmacológico da COVID-19
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article