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Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus.
Yu, Jieshi; Sreenivasan, Chithra; Uprety, Tirth; Gao, Rongyuan; Huang, Chen; Lee, Ella J; Lawson, Steven; Nelson, Julie; Christopher-Hennings, Jane; Kaushik, Radhey S; Nelson, Eric; Diel, Diego G; Hause, Ben M; Li, Feng; Wang, Dan.
Afiliação
  • Yu J; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
  • Sreenivasan C; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
  • Uprety T; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
  • Gao R; Department of Biology and Microbiology, South Dakota State University, Brookings, SD, USA.
  • Huang C; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
  • Lee EJ; Department of Biology and Microbiology, South Dakota State University, Brookings, SD, USA.
  • Lawson S; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD, USA.
  • Nelson J; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD, USA.
  • Christopher-Hennings J; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD, USA.
  • Kaushik RS; Department of Biology and Microbiology, South Dakota State University, Brookings, SD, USA.
  • Nelson E; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD, USA.
  • Diel DG; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Hause BM; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD, USA.
  • Li F; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
  • Wang D; Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA. dan.wang@uky.edu.
NPJ Vaccines ; 6(1): 22, 2021 Feb 01.
Article em En | MEDLINE | ID: mdl-33526776
ABSTRACT
Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article