The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells.

Nita, Akihiro; Muto, Yoshiharu; Katayama, Yuta; Matsumoto, Akinobu; Nishiyama, Masaaki; Nakayama, Keiichi I

Nita, Akihiro; Muto, Yoshiharu; Katayama, Yuta; Matsumoto, Akinobu; Nishiyama, Masaaki; Nakayama, Keiichi I.

Afiliação

Nita A; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Muto Y; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Katayama Y; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Matsumoto A; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan.
Nishiyama M; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan. Electronic address: nishiyam@staff.kanazawa-u.ac.jp.
Nakayama KI; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan. Electronic address: nakayak1@bioreg.kyushu-u.ac.jp.

Cell Rep ; 34(5): 108688, 2021 02 02.

Article em En | MEDLINE | ID: mdl-33535054

Assuntos

Transtorno do Espectro Autista/metabolismo; Transtorno do Espectro Autista/patologia; Caderinas/metabolismo; Células-Tronco Hematopoéticas/metabolismo; Células-Tronco Hematopoéticas/patologia; Animais; Transtorno do Espectro Autista/genética; Caderinas/genética; Diferenciação Celular/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteína Supressora de Tumor p53/genética

Palavras-chave

CHD8; apoptosis; bone marrow transplantation; cell cycle arrest; chromatin remodeler; colony formation assay; differentiation block; hematopoietic stem cell; p53; stemness

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Caderinas / Transtorno do Espectro Autista Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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