Simultaneous quantification of cefuroxime and clindamycin in human lumbar anulus fibrosus, nucleus pulposus and serum via UPLC-MS/MS.

Liang, Xiufang; Gou, Zhongping; Wang, Xiandi; Wang, Yongsheng; Yue, Jiao; Li, Na; Feng, Ping; Qin, Yongping; Zeng, Jiancheng

Liang, Xiufang; Gou, Zhongping; Wang, Xiandi; Wang, Yongsheng; Yue, Jiao; Li, Na; Feng, Ping; Qin, Yongping; Zeng, Jiancheng.

Afiliação

Liang X; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Gou Z; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Wang X; Department of Orthopaedic Surgery and Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Wang Y; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Yue J; West China School of Pharmacy, Sichuan University, Sichuan University, Chengdu, Sichuan 610041, PR China.
Li N; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Feng P; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: fengping@wchscu.cn.
Qin Y; Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: qinyping1@163.com.
Zeng J; Department of Orthopaedic Surgery and Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address: tomzeng5@163.com.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1165: 122522, 2021 Feb 15.

Article em En | MEDLINE | ID: mdl-33545501

Assuntos

Anel Fibroso/química; Cefuroxima/análise; Cromatografia Líquida de Alta Pressão/métodos; Clindamicina/análise; Núcleo Pulposo/química; Anel Fibroso/metabolismo; Cefuroxima/sangue; Cefuroxima/farmacocinética; Clindamicina/sangue; Clindamicina/farmacocinética; Humanos; Modelos Lineares; Região Lombossacral; Núcleo Pulposo/metabolismo; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Espectrometria de Massas em Tandem/métodos

Palavras-chave

Cefuroxime; Clindamycin; Human lumbar nucleus pulposus; Lumbar anulus fibrosus; Serum; UPLC-ESI-MS/MS

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clindamicina / Cefuroxima / Cromatografia Líquida de Alta Pressão / Anel Fibroso / Núcleo Pulposo Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google