A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIb&#945; and glycoprotein GPVI.

Sanchez, Eladio F; Alvarenga, Valeria G; Oliveira, Luciana S; Oliveira, Débora L; Estevao-Costa, Maria I; Flores-Ortiz, Renzo; Eble, Johannes A

A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbα and glycoprotein GPVI.

Sanchez, Eladio F; Alvarenga, Valeria G; Oliveira, Luciana S; Oliveira, Débora L; Estevao-Costa, Maria I; Flores-Ortiz, Renzo; Eble, Johannes A.

Afiliação

Sanchez EF; Research and Development Center, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil. Electronic address: eladio.flores@funed.mg.gov.br.
Alvarenga VG; Research and Development Center, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil.
Oliveira LS; Research and Development Center, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil.
Oliveira DL; Research and Development Center, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil.
Estevao-Costa MI; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany.
Flores-Ortiz R; Center for Data and Knowledge Integration for Health, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, BA, Brazil.
Eble JA; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany.

Biochimie ; 184: 1-7, 2021 May.

Article em En | MEDLINE | ID: mdl-33548391

Assuntos

Plaquetas/química; Metaloendopeptidases/química; Inibidores da Agregação Plaquetária/química; Complexo Glicoproteico GPIb-IX de Plaquetas/química; Glicoproteínas da Membrana de Plaquetas/química; Venenos de Serpentes/química; Animais; Plaquetas/metabolismo; Feminino; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Complexo Glicoproteico GPIb-IX de Plaquetas/metabolismo; Glicoproteínas da Membrana de Plaquetas/metabolismo

Palavras-chave

Antithrombotic; GPVI; Platelet receptors; Snake venom metalloproteinase; Thrombolytic

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Venenos de Serpentes / Plaquetas / Metaloendopeptidases / Inibidores da Agregação Plaquetária / Glicoproteínas da Membrana de Plaquetas / Complexo Glicoproteico GPIb-IX de Plaquetas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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