Mandelonitrile beta-glucuronide: synthesis and characterization.
Science
; 198(4317): 625-7, 1977 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-335509
ABSTRACT
Mandelonitrile beta-glucuronide, the compound patented as Laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with Salmonella typhimurium strains TA 98 and TA 100. Several commercial laetrile preparations contained no glucuronide; they contained amygdalin and neoamygdalin instead. Mandelonitrile, mandelonitrile glucuronide, and a mixture of amygdalin and neoamygdalin were each found to be mutagenic.
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Base de dados:
MEDLINE
Assunto principal:
Amigdalina
/
Mutação
/
Nitrilas
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article