Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αß T lymphocytes in untreated celiac disease.
Eur J Immunol
; 51(6): 1542-1545, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33559929
ABSTRACT
We compared the αß T-cell receptor repertoires of CD8+ αß intraepithelial lymphocytes from celiac disease patients and healthy subjects by single-cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
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Receptores de Antígenos de Linfócitos T alfa-beta
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Linfócitos T CD8-Positivos
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Epitélio
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article