Your browser doesn't support javascript.
loading
Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αß T lymphocytes in untreated celiac disease.
Eggesbø, Linn M; Risnes, Louise F; Neumann, Ralf S; Lundin, Knut E A; Christophersen, Asbjørn; Sollid, Ludvig M.
Afiliação
  • Eggesbø LM; K. G. Jebsen Centre for Coeliac Disease Research, University of Oslo, Oslo, Norway.
  • Risnes LF; K. G. Jebsen Centre for Coeliac Disease Research, University of Oslo, Oslo, Norway.
  • Neumann RS; Department of Immunology, University of Oslo and Oslo University Hospital- Rikshospitalet, Oslo, Norway.
  • Lundin KEA; K. G. Jebsen Centre for Coeliac Disease Research, University of Oslo, Oslo, Norway.
  • Christophersen A; K. G. Jebsen Centre for Coeliac Disease Research, University of Oslo, Oslo, Norway.
  • Sollid LM; Department of Gastroenterology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Eur J Immunol ; 51(6): 1542-1545, 2021 06.
Article em En | MEDLINE | ID: mdl-33559929
ABSTRACT
We compared the αß T-cell receptor repertoires of CD8+ αß intraepithelial lymphocytes from celiac disease patients and healthy subjects by single-cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Celíaca / Receptores de Antígenos de Linfócitos T alfa-beta / Linfócitos T CD8-Positivos / Epitélio Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Celíaca / Receptores de Antígenos de Linfócitos T alfa-beta / Linfócitos T CD8-Positivos / Epitélio Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article