Total synthesis of decarboxyaltenusin.
Beilstein J Org Chem
; 17: 224-228, 2021.
Article
em En
| MEDLINE
| ID: mdl-33564332
ABSTRACT
The total synthesis of decarboxyaltenusin (5'-methoxy-6-methyl-[1,1'-biphenyl]-3,3',4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps. The key reaction was a palladium-catalyzed Suzuki coupling of an aromatic boronate with a brominated resorcin derivative.
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MEDLINE
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En
Ano de publicação:
2021
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Article