Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, ßPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.

Cheng, Kunrong; Larabee, Shannon M; Tolaymat, Mazen; Hanscom, Marie; Shang, Aaron C; Schledwitz, Alyssa; Hu, Shien; Drachenberg, Cinthia B; Zhan, Min; Chahdi, Ahmed; Raufman, Jean-Pierre

Cheng, Kunrong; Larabee, Shannon M; Tolaymat, Mazen; Hanscom, Marie; Shang, Aaron C; Schledwitz, Alyssa; Hu, Shien; Drachenberg, Cinthia B; Zhan, Min; Chahdi, Ahmed; Raufman, Jean-Pierre.

Afiliação

Cheng K; Veterans Affairs Maryland Healthcare System, Baltimore, Maryland.
Larabee SM; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Tolaymat M; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Hanscom M; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Shang AC; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Schledwitz A; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Hu S; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Drachenberg CB; Veterans Affairs Maryland Healthcare System, Baltimore, Maryland.
Zhan M; Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland.
Chahdi A; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
Raufman JP; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

Am J Physiol Gastrointest Liver Physiol ; 320(4): G627-G643, 2021 04 01.

Article em En | MEDLINE | ID: mdl-33566751

Assuntos

Proliferação de Células; Colite/metabolismo; Colo/metabolismo; Enterócitos/metabolismo; Mucosa Intestinal/metabolismo; Microvilosidades/metabolismo; Fatores de Troca de Nucleotídeo Guanina Rho/deficiência; Animais; Células Cultivadas; Colite/induzido quimicamente; Colite/genética; Colite/patologia; Colo/patologia; Sulfato de Dextrana; Modelos Animais de Doenças; Enterócitos/patologia; Feminino; Deleção de Genes; Humanos; Mucosa Intestinal/patologia; Intestino Delgado/metabolismo; Intestino Delgado/patologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Microvilosidades/patologia; Organoides; Fatores de Troca de Nucleotídeo Guanina Rho/genética; Fatores de Troca de Nucleotídeo Guanina Rho/metabolismo; Transdução de Sinais; Técnicas de Cultura de Tecidos; Quinases Associadas a rho/metabolismo

Palavras-chave

Rho-associated protein kinase; cell proliferation; dextran sodium sulfate colitis; intestinal epithelial cells; intestinal organoids; ß-catenin signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite / Colo / Enterócitos / Proliferação de Células / Fatores de Troca de Nucleotídeo Guanina Rho / Mucosa Intestinal / Microvilosidades Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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