Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions.
Org Lett
; 23(5): 1851-1855, 2021 03 05.
Article
em En
| MEDLINE
| ID: mdl-33570414
ABSTRACT
Aryl diazonium ions are important in synthesis and chemical biology, and the acid-labile triazabutadiene can protect this handle for future use. We report a Suzuki coupling strategy that is compatible with the triazabutadiene scaffold, expanding the scope of synthetically available triazabutadienes. Shown herein, the triazabutadiene scaffold remains intact and reactive after coupling, as demonstrated by releasing the aryl diazonium ion to label a tyrosine-rich model protein.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Compostos de Diazônio
/
Íons
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article