Experimental and Computational Evaluation of Chloranilic Acid as an Universal Chromogenic Reagent for the Development of a Novel 96-Microwell Spectrophotometric Assay for Tyrosine Kinase Inhibitors.

Darwish, Ibrahim A; Darwish, Hany W; Khalil, Nasr Y; Sayed, Ahmed Y A

Darwish, Ibrahim A; Darwish, Hany W; Khalil, Nasr Y; Sayed, Ahmed Y A.

Afiliação

Darwish IA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Darwish HW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Khalil NY; Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.
Sayed AYA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Molecules ; 26(3)2021 Jan 31.

Article em En | MEDLINE | ID: mdl-33572664

Assuntos

Benzoquinonas/farmacologia; Modelos Moleculares; Inibidores de Proteínas Quinases/farmacologia; Proteínas Tirosina Quinases/antagonistas & inibidores; Benzoquinonas/química; Desenho de Fármacos; Conformação Molecular; Inibidores de Proteínas Quinases/química; Espectrofotometria; Termodinâmica

Palavras-chave

96-microwell spectrophotometric assay; charge-transfer reaction; chloranilic acid; high-throughput pharmaceutical analysis; tyrosine kinase inhibitors

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Modelos Moleculares / Benzoquinonas / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google