PINK1-Mediated Inhibition of EGFR Dimerization and Activation Impedes EGFR-Driven Lung Tumorigenesis.

Lin, Emily Pei-Ying; Huang, Bo-Tsang; Lai, Wei-Yun; Tseng, Yi-Ting; Yang, Shuenn-Chen; Kuo, Hao-Cheng; Yang, Pan-Chyr

Lin, Emily Pei-Ying; Huang, Bo-Tsang; Lai, Wei-Yun; Tseng, Yi-Ting; Yang, Shuenn-Chen; Kuo, Hao-Cheng; Yang, Pan-Chyr.

Afiliação

Lin EP; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Huang BT; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Lai WY; Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.
Tseng YT; Departments of Medical Research and Internal Medicine, Fu Jen Catholic University Hospital and College of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Yang SC; Clinical Trial Center, Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Kuo HC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yang PC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Cancer Res ; 81(7): 1745-1757, 2021 04 01.

Article em En | MEDLINE | ID: mdl-33574089

Assuntos

Adenocarcinoma de Pulmão; Neoplasias Pulmonares; Proteínas Quinases/fisiologia; Multimerização Proteica; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/metabolismo; Adenocarcinoma de Pulmão/patologia; Animais; Carcinogênese/genética; Carcinogênese/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/genética; Estudos de Coortes; Regulação para Baixo; Receptores ErbB/metabolismo; Células HEK293; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Multimerização Proteica/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Multimerização Proteica / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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