Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress.
Biomed Res Int
; 2021: 8109134, 2021.
Article
em En
| MEDLINE
| ID: mdl-33575344
ABSTRACT
Bone morphogenetic proteins (BMPs), a member of the transforming growth factor ß (TGF-ß) superfamily, are abundant in human ocular tissues and play an important role in lens development. Targeted deletion of BMP-4 in mice results in failure of lens placode formation. Following lens maturation, the formation of senile cataracts is demonstrably associated with free radical-related oxidative stress. Previous studies reported that BMPs play an antiapoptotic role in cells under oxidative stress, and the BMP-4 signal is important in inflammation regulation and homeostasis. BMP-4 evidently suppressed the apoptosis of human lens epithelial cells (HLECS) under oxidative stress induced by H2O2. This protective antiapoptotic effect is partly due to a decrease in caspase-3 activity and reactive oxygen species (ROS) level. Furthermore, the expression of activating transcription factor- (ATF-) 6 and Krüppel-like factor- (KLF-) 6 increased under oxidative stress and decreased after BMP-4 treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Apoptose
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Estresse Oxidativo
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Substâncias Protetoras
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Proteína Morfogenética Óssea 4
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Cristalino
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article