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Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome.
D'Acunzo, Pasquale; Pérez-González, Rocío; Kim, Yohan; Hargash, Tal; Miller, Chelsea; Alldred, Melissa J; Erdjument-Bromage, Hediye; Penikalapati, Sai C; Pawlik, Monika; Saito, Mitsuo; Saito, Mariko; Ginsberg, Stephen D; Neubert, Thomas A; Goulbourne, Chris N; Levy, Efrat.
Afiliação
  • D'Acunzo P; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Pérez-González R; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
  • Kim Y; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Hargash T; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
  • Miller C; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Alldred MJ; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
  • Erdjument-Bromage H; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Penikalapati SC; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Pawlik M; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Saito M; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
  • Saito M; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
  • Ginsberg SD; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
  • Neubert TA; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Goulbourne CN; Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
  • Levy E; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
Sci Adv ; 7(7)2021 02.
Article em En | MEDLINE | ID: mdl-33579698
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. We term these newly identified mitochondria-derived EVs "mitovesicles." We demonstrate that brain-derived mitovesicles contain a specific subset of mitochondrial constituents and that their levels and cargo are altered during pathophysiological processes where mitochondrial dysfunction occurs, including in DS. The development of a method for the selective isolation of mitovesicles paves the way for the characterization in vivo of biological processes connecting EV biology and mitochondria dynamics and for innovative therapeutic and diagnostic strategies.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Exossomos / Doença de Alzheimer / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Exossomos / Doença de Alzheimer / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article