High mobility group box 1 and angiogenetic growth factor levels in children with central nerve system infections.
J Infect Chemother
; 27(6): 840-844, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33583741
ABSTRACT
INTRODUCTION:
To clarify the pathology of children with acute encephalopathy and other neurological disorders, the involvement of high-mobility group box 1 (HMGB1), which is a representative of danger-associated molecular patterns, and angiogenesis-related growth factors were investigated. PATIENTS ANDMETHODS:
Participants were 12 children with acute encephalopathy (influenza, rotavirus, and others), 7 with bacterial meningitis, and 6 with epilepsy disease (West syndrome). Twenty-four patients with non-central nervous system (CNS) infections as a control group were admitted to our hospital. We examined the levels of HMGB1, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and other cytokines in the serum and cerebrospinal fluid (CSF) of the subjects.RESULTS:
Serum and CSF HMGB1 levels were significantly higher in the encephalopathy and meningitis groups than in the West syndrome and control groups. CSF HMGB1 levels correlated with those of interleukin-6 and -8. CSF HMGB1 and VEGF levels were correlated, and PDGF showed a positive relationship.CONCLUSION:
HMGB1 and angiogenesis-related growth factors appear to play pivotal roles in the pathophysiology of CNS infections.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Infecções do Sistema Nervoso Central
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Proteína HMGB1
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Influenza Humana
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article