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Oral Immunotherapy With Human Secretory Immunoglobulin A Improves Survival in the Hamster Model of Clostridioides difficile Infection.
Chiari, Estelle F; Weiss, William; Simon, Michael R; Kiessig, Stephan T; Pulse, Mark; Brown, Stephen C; Gerding, Hanne R; Mandago, Maurice; Gisch, Karina; von Eichel-Streiber, Christoph.
Afiliação
  • Chiari EF; Secretory IgA, Inc, Ann Arbor, Michigan, USA.
  • Weiss W; Preclinical Services, University of North Texas Health Science Center-College of Pharmacy, Fort Worth, Texas, USA.
  • Simon MR; Secretory IgA, Inc, Ann Arbor, Michigan, USA.
  • Kiessig ST; Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, Michigan, USA.
  • Pulse M; Department of Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
  • Brown SC; Departments of Internal Medicine and Pediatrics (Clinical Emeritus), Wayne State University School of Medicine, Detroit, Michigan, USA.
  • Gerding HR; PreviPharma, GmbH, Mannheim, Germany.
  • Mandago M; Preclinical Services, University of North Texas Health Science Center-College of Pharmacy, Fort Worth, Texas, USA.
  • Gisch K; Secretory IgA, Inc, Ann Arbor, Michigan, USA.
  • von Eichel-Streiber C; PreviPharma, GmbH, Mannheim, Germany.
J Infect Dis ; 224(8): 1394-1397, 2021 10 28.
Article em En | MEDLINE | ID: mdl-33588433
ABSTRACT
Coadministration of human secretory IgA (sIgA) together with subtherapeutic vancomycin enhanced survival in the Clostridioides difficile infection (CDI) hamster model. Vancomycin (5 or 10 mg/kg × 5 days) plus healthy donor plasma sIgA/monomeric IgA (TID × 21 days) or hyperimmune sIgA/monomeric IgA (BID × 13 days) enhanced survival. Survival was improved compared to vancomycin alone, P = .018 and .039 by log-rank Mantel-Cox, for healthy and hyperimmune sIgA, respectively. Passive immunization with sIgA (recombinant human secretory component plus IgA dimer/polymer from pooled human plasma) can be administered orally and prevents death in a partially treated CDI hamster model.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina A Secretora / Vancomicina / Clostridioides difficile / Infecções por Clostridium / Imunoterapia / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina A Secretora / Vancomicina / Clostridioides difficile / Infecções por Clostridium / Imunoterapia / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article