Understanding axial progenitor biology in vivo and in vitro.
Development
; 148(4)2021 02 16.
Article
em En
| MEDLINE
| ID: mdl-33593754
ABSTRACT
The generation of the components that make up the embryonic body axis, such as the spinal cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction. This process is driven by the coordinated production of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments in the in vitro production of axial progenitors and their potential implications in disease modelling and regenerative medicine.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia
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Padronização Corporal
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Gastrulação
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Camadas Germinativas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article