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Immunotherapy for pancreatic ductal adenocarcinoma.
Carpenter, Eileen; Nelson, Sarah; Bednar, Filip; Cho, Clifford; Nathan, Hari; Sahai, Vaibhav; di Magliano, Marina Pasca; Frankel, Timothy L.
Afiliação
  • Carpenter E; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
  • Nelson S; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Bednar F; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Cho C; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Nathan H; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Sahai V; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • di Magliano MP; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • Frankel TL; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
J Surg Oncol ; 123(3): 751-759, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33595893
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the efficacy of immunotherapy, particularly given the hallmarks of immune suppression and exhaustion in PDAC tumors. Here, we review the molecular components responsible for the immune-privileged state in PDAC and provide an overview of the immunotherapeutic strategies for PDAC including vaccine therapy, checkpoint blockade, myeloid-targeted therapy, and immune agonist therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Imunoterapia Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Imunoterapia Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article