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Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation.
Wyckelsma, Victoria L; Venckunas, Tomas; Houweling, Peter J; Schlittler, Maja; Lauschke, Volker M; Tiong, Chrystal F; Wood, Harrison D; Ivarsson, Niklas; Paulauskas, Henrikas; Eimantas, Nerijus; Andersson, Daniel C; North, Kathryn N; Brazaitis, Marius; Westerblad, Håkan.
Afiliação
  • Wyckelsma VL; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Venckunas T; Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
  • Houweling PJ; Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia; Department of Paediatrics, Melbourne Medical School, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Schlittler M; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Lauschke VM; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Tiong CF; Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia; Department of Paediatrics, Melbourne Medical School, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Wood HD; Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia; Department of Paediatrics, Melbourne Medical School, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Ivarsson N; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Paulauskas H; Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
  • Eimantas N; Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania.
  • Andersson DC; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden; Heart, Vascular and Neurology Theme, Cardiology unit, Karolinska University Hospital, 171 76 Stockholm, Sweden.
  • North KN; Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Melbourne, VIC 3052, Australia; Department of Paediatrics, Melbourne Medical School, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Brazaitis M; Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania. Electronic address: marius.brazaitis@lsu.lt.
  • Westerblad H; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 171 77 Stockholm, Sweden; Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 Kaunas, Lithuania. Electronic address: hakan.westerblad@ki.se.
Am J Hum Genet ; 108(3): 446-457, 2021 03 04.
Article em En | MEDLINE | ID: mdl-33600773
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinina / Termogênese Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinina / Termogênese Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article