In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs.
J Pharmacol Sci
; 145(3): 268-272, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33602507
ABSTRACT
We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isoflurane from 1.5% to 2.5% decreased the mean blood pressure and prolonged the QRS width without significantly altering the heart rate, PR interval or QT interval. However, the observed changes disappeared after regressions of both anesthetic conditions to their initial settings. These results indicate that hypotension-induced, reflex-mediated increase of sympathetic tone may have counterbalanced the direct negative chronotropic, dromotropic and repolarization slowing effects of the anesthetics.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Eletrocardiografia
/
Halotano
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Hemodinâmica
/
Isoflurano
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Anestésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article