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Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study.
Kraus, Sarah M; Shaboodien, Gasnat; Francis, Veronica; Laing, Nakita; Cirota, Jacqui; Chin, Ashley; Pandie, Shahiemah; Lawrenson, John; Comitis, George A M; Fourie, Barend; Zühlke, Liesl; Wonkam, Ambroise; Wainwright, Helen; Damasceno, Albertino; Mocumbi, Ana Olga; Pepeta, Lungile; Moeketsi, Khulile; Thomas, Baby M; Thomas, Kandathil; Makotoko, Makoali; Brown, Stephen; Ntsekhe, Mpiko; Sliwa, Karen; Badri, Motasim; Gumedze, Freedom; Cordell, Heather J; Keavney, Bernard; Ferreira, Vanessa; Mahmod, Masliza; Cooper, Leslie T; Yacoub, Magdi; Neubauer, Stefan; Watkins, Hugh; Mayosi, Bongani M; Ntusi, Ntobeko A B.
Afiliação
  • Kraus SM; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Shaboodien G; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Francis V; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Laing N; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa; Division of Human Genetics, Department of Medicine, UCT, Cape Town, South Africa.
  • Cirota J; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Chin A; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Pandie S; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Lawrenson J; Division of Paediatric Cardiology, Department of Paediatrics and Child Health, UCT and Red Cross War Memorial Children's Hospital, Cape Town, South Africa; Division of Paediatric Cardiology, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Hospital, Cape Town, South
  • Comitis GAM; Division of Paediatric Cardiology, Department of Paediatrics and Child Health, UCT and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
  • Fourie B; Division of Paediatric Cardiology, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  • Zühlke L; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa; Division of Paediatric Cardiology, Department of Paediatrics and Child Health, UCT and Red Cross War Memorial Child
  • Wonkam A; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa; Division of Human Genetics, Department of Medicine, UCT, Cape Town, South Africa.
  • Wainwright H; Department of Pathology, National Health Laboratory Service and UCT, Cape Town, South Africa.
  • Damasceno A; Department of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
  • Mocumbi AO; Instituto Nacional de Saúde and Eduardo Mondlane University, Maputo, Mozambique.
  • Pepeta L; Department of Paediatrics, Port Elizabeth Hospital Complex and Nelson Mandela Metropolitan University, Port Elizabeth, South Africa.
  • Moeketsi K; Division of Cardiology, Nelson Mandela Academic Hospital and Walter Sisulu University, Mthatha, South Africa.
  • Thomas BM; Division of Cardiology, Nelson Mandela Academic Hospital and Walter Sisulu University, Mthatha, South Africa.
  • Thomas K; Division of Cardiology, Nelson Mandela Academic Hospital and Walter Sisulu University, Mthatha, South Africa.
  • Makotoko M; Division of Cardiology, Universitas Hospital and University of the Free State, Bloemfontein, South Africa.
  • Brown S; Division of Cardiology, Universitas Hospital and University of the Free State, Bloemfontein, South Africa.
  • Ntsekhe M; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Sliwa K; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Badri M; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa; College of Medicine, King Saudi Bin Abdulaziz University for Medical Sciences, Riyadh, Saudi Arabia.
  • Gumedze F; Department of Statistics, UCT, Cape Town, South Africa.
  • Cordell HJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Keavney B; Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
  • Ferreira V; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Mahmod M; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Cooper LT; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, USA.
  • Yacoub M; Heart Science Centre, Harefield, London, UK.
  • Neubauer S; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Watkins H; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Mayosi BM; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa.
  • Ntusi NAB; The Cardiac Clinic and Hatter Institute of Cardiovascular Research in Africa, Department of Medicine, University of Cape Town (UCT) and Groote Schuur Hospital, Cape Town, South Africa. Electronic address: Ntobeko.Ntusi@uct.ac.za.
Int J Cardiol ; 333: 119-126, 2021 06 15.
Article em En | MEDLINE | ID: mdl-33607192
ABSTRACT

BACKGROUND:

Heart failure (HF), the dominant form of cardiovascular disease in Africans, is mainly due to hypertension, rheumatic heart disease and cardiomyopathy. Cardiomyopathies pose a great challenge because of poor prognosis and high prevalence in low- and middle-income countries (LMICs). Little is known about the etiology and outcome of cardiomyopathy in Africa. Specifically, the role of myocarditis and the genetic causes of cardiomyopathy are largely unidentified in Africans.

METHOD:

The African Cardiomyopathy and Myocarditis Registry Program (the IMHOTEP study) is a pan-African multi-centre, hospital-based cohort study, designed with the primary aim of describing the clinical characteristics, genetic causes, prevalence, management and outcome of cardiomyopathy and myocarditis in children and adults. The secondary aim is to identify barriers to the implementation of evidence-based care and provide a platform for trials and other intervention studies to reduce morbidity and mortality in cardiomyopathy. The registry consists of a prospective cohort of newly diagnosed (i.e., incident) cases and a retrospective (i.e., prevalent) cohort of existing cases from participating centres. Patients with cardiomyopathy and myocarditis will be subjected to a standardized 3-stage diagnostic process. To date, 750 patients have been recruited into the multi-centre pilot phase of the study.

CONCLUSION:

The IMHOTEP study will provide comprehensive and novel data on clinical features, genetic causes, prevalence and outcome of African children and adults with all forms of cardiomyopathy and myocarditis in Africa. Based on these findings, appropriate strategies for management and prevention of the cardiomyopathies in LMICs are likely to emerge.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatias / Miocardite Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Humans País como assunto: Africa Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiomiopatias / Miocardite Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Humans País como assunto: Africa Idioma: En Ano de publicação: 2021 Tipo de documento: Article